Piperacillin sodium and tazobactam sodium monograph for. Piperacillin sodiumtazobactam sodium powder for injection. Piperacillin sodium and tazobactam sodium for injection addvantage. Pediatric guidelines for iv medication administration note.
Zosyn is a combination product consisting of a penicillinclass antibacterial, piperacillin, and a. All of the linezolid admixtures with aztreonam and with piperacillin sodium were clear when viewed in normal fluorescent room light and with a tyndall beam. Apr 28, 2020 initial presumptive treatment of patients with nosocomial pneumonia should start with zosyn at a dosage of 4. The usual total daily dose of zosyn for adults is 3. Zosyn intravenous interactions with other medication. The dose and administration iv infusion rate for potassium phosphates are dependent upon individual needs of the patient. Piperacillin and tazobactam zosyn is a combination of two antibiotics prescribed to treat a variety of bacterial infections such as pneumonia, appendicitis, pelvic inflammatory disease, e. Dailymed zosyn piperacillin sodium and tazobactam sodium. The usual duration of zosyn treatment is from 7 to 10 days. Each vial contains less than 1mmol of both potassium and sodium. Potassium phosphates iv dosing, indications, interactions.
Critical care intravenous drug administration guide. Intravenous compatibility chart drug information for. Ysite injection drug compatibility chart for critical. On april 24, 2020, the us fda approved menquadfitm meningococcal vaccine, tetanus toxoid conjugate quadrivalent im injection indicated for active immunization for the prevention of invasive meningococcal disease caused by neisseria meningitidis serogroups a, c, w, and y in individuals 2 years of age and older. Vancomycin and piperacillintazobactam combination therapy. For blood therapy, it is recommended that a 4 french or. Zosyn should be administered by intravenous infusion over 30 minutes.
Potassium losing diuretics, corticosteroids,oramphotericin b mayqrisk of hypokalemia. Phosphorous serum level piperacillin tazobactam, her serum potassium level was 4. Potassium chloride and zosyn drug interactions a study of. Meropenem 60 mgkg per day iv in three divided doses, up to a maximum of 6 gday. Drug manufacturer lot number concentrationa albumin, human zlb biopharma 0431900087 25%b aminophylline american regent 4021 2. Compatibility depends upon many factors including temperature, ph, iv fluid, concentration, order of mixing and brand of drug. Thames valley ysite intravenous drugs compatibility chart march. Zosyn is not chemically stable in solutions that contain only sodium bicarbonate and solutions that significantly alter the ph. Watson is in medical residency and can answer many drug information questions.
Zosyn piperacillin and tazobactam for injection, usp contains a total of 2. Dec 16, 2007 so today pt pt was ordered a heparin drip and iv abx. Zosyn over 4 hrs page 2 patient medications allnurses. Intravenous compatibility chart acyclovir acyclovir. If iv access or medication timing is a problem, the pharmacist may convert the order to the equivalent intermittent dosingregimen without a physicians order but must document the intervention. Piperacillin is an antibiotic, and tazobactam is a betalactamase inhibitor, which prevents resistance to. Plasmalyte 148 injection multiple electrolytes injection, type 1, usp should be used with great care, if at all, in patients with hyperkalemia, severe renal failure.
Zosyn piperacillintazobactam dose, indications, adverse. Caution should be exercised in premature neonates due to aluminum toxicity. Compatible intravenous solutions for pharmacy and single dose vials. You should also ensure that the drugs checked are compatible in terms of carrier fluid. Compatibility is denoted by an icon and simple description.
Review side effects, drug interactions, dosage, and pregnancy safety information prior to taking. Zosyn piperacillin and tazobactam injection, for intravenous use. The study is based on potassium chloride and piperacillin sodium. Incompatibilities are based on meeting any of the following criteria. Iv ysite infusion solutioncompatibility data infusion solution compatible. Automatically adjust timing of zosyn to be separated from vancomycin or other iv medications to avoid compatibility issues, if applicable. Pediatric guidelines for iv medication administration. Ysite injection drug compatibility chart for critical care wards key to symbols. Ysite injection drug compatibility chart for general. Extendedinfusion piperacillintazobactam zosyn compatibility. Zosyn should not be mixed with other drugs in a syringe or infusion bottle since compatibility has not been established.
At first it was just for renal patients with off the wall buncreatine levels, now it is protocol for e. Ysite injection drug compatibility chart for critical care wards. So i am not quite sure what literature you are actually reading. Capitals indicate lifethreatening, underlines indicate most frequent. Check tubing below ysite carefully for discoloration, cloudiness or precipitation blank do not mix.
How to use zosyn solution, piggyback premix frozen. Monographs for commonly administered intravenous medications in home and. The administration of acetate or gluconate ions should be done with great care in those conditions in which there is an increased level or an impaired utilization of these ions, such. For additional information or clarification, call pharmacy. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Heparin drip compatibilty patient medications allnurses.
Jul 17, 2010 at my hospital we used to infuse zosyn 2. These highlights do not include all the information needed to use zosyn safely and effectively. Zosyn fda prescribing information, side effects and uses. Device indications for use contraindications midline catheters indicated for short or long term peripheral access to the peripheral venous system for selected intravenous therapies and blood sampling. Iv ysite infusion solution compatibility data infusion solution compatible. Zosyn is typically given three to four times a day or once every 6 hours over 30 minutes through an iv solution that drips through a needle or catheter in the vein or is infused by a pump. Compatibility and stability of linezolid injection admixed. Potassiumlosing diuretics, corticosteroids,oramphotericin b.
A legend at the bottom of the page lists all compatibility types, and hovering your mouse over the icon will open a popup with the full. The system learns from interaction with users and will be able to answer more sophisticated questions over time. Parenteral nutrition pn and drug compatibility the coinfusion of drugs and pn should be avoided. I am now looking at the monograph for zosyn in intravenous medications, the mosby book. Iv drug compatibility chart the iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Zosyn piperacillin and tazobactam for injection, for intravenous use.
May 29, 2019 zosyn is not compatible with tobramycin for simultaneous coadministration via ysite infusion. There are some issues with chemical compatibility and there is a warning about phlebitis, but not mention of tissue damage with extravasation. Ysite injection drug compatibility chart for general wards. This table can be used for ysite compatibility at the usual manufacturers concentrations. If youre on a low or nosodium diet because of your kidneys, or if youre taking medicines that affect your potassium blood pressure medications like lasix or a water pill, your doctor might have to change them. Initial presumptive treatment of patients with nosocomial pneumonia should start with zosyn at a dosage of 4. Drugs administered to patients receiving pn should be given through a separate iv site or catheter lumen. Monographs for commonly administered intravenous medications. Recently our hospital has changed protocol to infuse 3. On the 1st postoperative day, before starting piperacillin tazobactam, her serum potassium level was 4. Plasmalyte 148 injection multiple electrolytes injection.
Monographs for commonly administered intravenous medications in home and community care references. Intravenous compatibility chart drug information for the. Iv compatibility results are organized onto separate tabs, so that you can quickly access the route or method in which you are interested. Piperacillintazobactam 300 mgkg per day iv in four divided doses up to a maximum of 12 gday, or. Zosyn is a combination medication that contains two drugs, piperacillin and tazobactam. Plasmalyte 148 injection multiple electrolytes injection, type 1, usp should be used with great care, if at all, in patients with hyperkalemia, severe renal failure, and in conditions in which potassium retention is present.
Compatibility of zosyn with other aminoglycosides has not been established. Pn solutions are diverse in their composition and compatibilities with drugs can never be guaranteed. This medication is given by injection into a vein as directed by your doctor, usually every 6 hours. For blood therapy, it is recommended that a 4 french or larger catheter be used.
Ucsf medical center extended infusion zosyn protocol 16. One abx was vanco which is not compatible with heparin the other abx was azactam sp. Pdf hospital pharmacies in many countries include a mix of both european and fda approved medications in their formulary. Compatibility depends upon many factors including temperature, ph, iv fluid, concentration, order of mixing and brand of. Zosyn piperacillin and tazobactam for injection, usp the.
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